At least 299 passengers and 22 crew members sailing on a Princess Cruises ship are believed to be suffering from suspected norovirus.
Caribbean Princess was refused entry to Trinidad & Tobago as a precautionary measure.
The ship was on a 14-day Caribbean sailing which departed on February 2.
It is now en route back to Port Everglades, Florida, and is scheduled to arrive Thursday morning.
The ship is carrying 4,196 guests and crew in total.
All guests are being offered a 50% refund and a future cruise credit.
The US Centers for Disease Control and Prevention said the ship will undergo a “super sanitation cleaning” in port on February 16.
It will then depart from Port Everglades for a round-trip Circle Caribbean cruise.
The line is also dealing with an outbreak of coronavirus onboard Diamond Princess in Japan, where 136 passengers have been diagnosed with the virus.
Meanwhile, on Monday, Saga Cruises confirmed at least 89 passengers on board Spirit of Discovery were suffering from suspected norovirus with guests showing symptoms including vomiting, diarrhoea and fever.
The authorities in Gibraltar refused the ship entry and it is now en route back to Southampton.
A Princess Cruises spokesperson said: “Caribbean Princess, which had been on a 14-day cruise in the Caribbean, has curtailed its current voyage due to guests reporting symptoms consistent with a mild case of gastrointestinal illness.
“The affected guests are being treated by the onboard medical team and there are no cases of coronavirus identified among guests or crew.
“The ship, with 4,196 guests and crew, is now sailing back to the Port of Everglades in Fort Lauderdale, and is scheduled to arrive at Port Everglades at 7:00am on Thursday, February 13.
“This is a highly unusual development and we share the disappointment of our guests. However, the health and safety of our guests and crew is our top priority, and we have worked alongside the U.S. Centers for Disease Control and Prevention (CDC) to make this decision.
“All guests will receive a 50% refund on their voyage and a future cruise credit valued at 50% of their cruise for this inconvenience.
“Caribbean Princess will resume its schedule with a February 16 departure from Port Everglades for a round-trip Circle Caribbean cruise.”